Milind Pande
Teerthankar Mahaveer University, India
Title: Some studies on preparation and evaluation of microspheres containing homeopathic mother tincture of Nux- vomica
Biography
Biography: Milind Pande
Abstract
The mother tincture of Strychnos nuxvomica Linn. Family Logaaniaceae have been used in homeopathic medicinal system since ancient times for the treatment of male stomach disorders. The present study is aimed to investigate the effect of alcoholic mother tincture of Nux-vomica on peptic ulcer patients with converting the tincture in microspheres. The seeds of Nux-vomica were purchased from local market and identified through university taxonomist for authentication purpose. After drying at 40-50 0C converted into coarse material were subjected to maceration with ethanol 95% for three days at room temperature. After recovery of ethanol 90% all mother tincture allowed to dry completely in powder form used for preparation of microspheres with polymer ethyl cellulose: Test drug ratio (1:1. 500 mg) in 10 ml of acetone. In separate
beaker 0.2% solution of sodium lauryl sulphate (600 mg in 300 ml of distill water). The test drug solution with polymer in surfactant solution was added drop by drop with constant stirring (speed 1000 to 1200 rpm). Then suspension was allowed to cool at room temperature, filtered and obtained microspheres dried in vacuum desiccator in overnight with stored in 4 0C in dark. Further the evolutions of microspheres were done by physic chemical methods such as % yield, particle size analysis, bulk density, angle of repose and particle shape analysis. The results indicated that the ethanolic mother tincture of Strychnos nuxvomica Linn. Family Logaaniaceae produced a significant and sustained quality of microspheres which can be used to enhance bioavailability and fast release to small and large intestine inner cell lining and will help in treatment
of peptic ulcer, stomach ache and constipation in chronic cases. As homeopathic formulation have only oral route of administration this microspheres can be formulated in various formulations like capsules, tablets or injections as per need of patient for fastest effect with suitable human trials.